A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans



A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans.


To evaluate acute effects of bovine colostrum low-molecular weight fraction (CLMWF) on selected aspects of innate immune function in healthy human subjects.


A placebo-controlled, double-blinded, randomized cross-over trial involving 12 healthy subjects, age 22-72, was conducted at NIS Labs during the year 2010. Placebo or 150 mg CLMWF was given orally. Blood was drawn immediately before and at 1 and 2h after consumption.


A single dose of CLMWF, when compared to placebo, resulted in rapid increase in phagocytic activity of monocytes at 1h (P<0.12) and polymorphonuclear cells at 1h (P<0.08) and 2h (P<0.03) after consumption. Observations included increased numbers of CD3(+) T cells (P<0.05), and a transient reduction in circulating CD3(-)CD56(+) natural killer (NK) cells at 1h (P<0.04), returning to normal levels at 2h after consumption (P<0.96). The relative increase of NK cells from 1 to 2h after consumption was not associated with an increase in CD69 or CD25 activation markers, suggesting that new NK cells were mobilized into circulation.


The increased phagocytic activity and rapid transient changes in NK cell numbers suggest that upon consumption, interaction of CLMWF with immune cells in the gut mucosa triggers immediate events with systemic consequences.

Published on the website ScienceDirect, which provides open access to large data directories of scientific and medical publications by Dutch publisher Elsevier, with more than 18 million pieces of content.


  1. Habar, T. R., Islam, A. A., Hatta, M., Mahmudi, A., Massi, M. N., Bukhari, A., … & Mappiwali, A. (2021). Transfer factor treatment in management of peritonitis condition: An experimental study in rat. Annals of Medicine and Surgery, 69, 102755.
  2. Wong, E. B., Mallet, J. F., Duarte, J., Matar, C., & Ritz, B. W. (2014). Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutrition Research, 34(4), 318-325.
  3. Aruoma, O. I., Coles, L. S., Landes, B., & Repine, J. E. (2012). Functional benefits of ergothioneine and fruit-and vegetable-derived nutraceuticals: overview of the supplemental issue contents. Preventive Medicine, 54, S4-S8.
  4. Morabia, A., & Costanza, M. C. (2012). Aging medicine: Not evidence-based medicine yet. Preventive Medicine, (54), S1-S3.
  5. Ghosh, S., & Iacucci, M. (2021). Diverse immune effects of bovine colostrum and benefits in human health and disease. Nutrients, 13(11), 3798.
  6. Shao, T., Verma, H. K., Pande, B., Costanzo, V., Ye, W., Cai, Y., & Bhaskar, L. V. K. S. (2021). Physical activity and nutritional influence on immune function: an important strategy to improve immunity and health status. Frontiers in Physiology, 1702.
Maybe you are interested

Nutrient Intake in Vietnamese Preschool and School-Aged Children is Not Adequate: The Role of Dairy

Background The traditional Vietnamese diet carries the risk of micronutrient deficiencies, and a substantial part of children <11 years do...
See more

Nutritional principles in diabetes treatment as recommended by the American Diabetes Association (ADA) Copy

Lifestyle and diet adjustment is the top priority treatment method for people with diabetes. This is also the most challenging...
See more

Vietnam Recommended Dietary Allowances 2007

It has been well acknowledged that Vietnam is undergoing a nutrition transition. With a rapid change in the country’s reform...
See more