Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial

09/05/2023

RESEARCH

Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial.

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Objectives

To evaluate the effect of bovine colostrum (BC) on the treatment of children with acute diarrhea attending the outpatient clinic.

Methods

This double-blind randomized controlled trial was conducted on 160 children with diarrhea; 80 cases were randomly treated with BC group and 80 cases randomly received placebo (placebo group). All cases were investigated for bacterial causes of diarrhea (Salmonella spp, Shigella spp, diarrheagenic E. coli (DEC), Campylobacter spp., and Vibrio cholerae) as well as for Rotavirus antigen in stool.

Results

After 48 h, the BC group had a significantly lower frequency of vomiting, diarrhea and Vesikari scoring compared with the placebo group (p = 0.000, p = 0.000, p = 0.000, respectively), whether it was due to Rotavirus or E. coli infection.

Conclusions

BC is effective in the treatment of acute diarrhea and can be considered as adjuvant therapy in both viral and bacterial diarrhea to prevent diarrhea-related complications.

Published in the National Library of Medicine – National Center for Biotechnology Information, under the auspices of the US Government.

REFERENCES

  1. Mehra, R., Garhwal, R., Sangwan, K., Guiné, R. P., Lemos, E. T., Buttar, H. S., … & Kumar, H. (2022). Insights into the research trends on bovine colostrum: Beneficial health perspectives with special reference to manufacturing of functional foods and feed supplements. Nutrients, 14(3), 659.
  2. Kaplan, M., Arslan, A., Duman, H., Karyelioğlu, M., Baydemir, B., Günar, B. B., … & Karav, S. (2022). Production of bovine colostrum for human consumption to improve health. Frontiers in Pharmacology, 12, 796824.
  3. Sangild, P. T., Vonderohe, C., Melendez Hebib, V., & Burrin, D. G. (2021). Potential benefits of bovine colostrum in pediatric nutrition and health. Nutrients, 13(8), 2551.
  4. Carter, H. S., Renaud, D. L., Steele, M. A., Fischer-Tlustos, A. J., & Costa, J. H. (2021). A narrative review on the unexplored potential of colostrum as a preventative treatment and therapy for diarrhea in neonatal dairy calves. Animals, 11(8), 2221.
  5. Xue, Z., Han, Q., Huang, P., Jiang, X., Tan, M., Zhao, Y., … & Zhang, R. (2021). Characterization of functional components in bovine colostrum that inhibit norovirus capsid protruding domains interacting with HBGA ligands. Pathogens, 10(7), 857.
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